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Necrostatin-34
CAS No. 375835-43-1
Necrostatin-34 ( 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 )
Catalog No. M24335 CAS No. 375835-43-1
Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 177 | In Stock |
|
| 10MG | 260 | In Stock |
|
| 25MG | 483 | In Stock |
|
| 50MG | 698 | In Stock |
|
| 100MG | 972 | In Stock |
|
| 500MG | 1953 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNecrostatin-34
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NoteResearch use only, not for human use.
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Brief DescriptionNecrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
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DescriptionNecrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
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Synonyms2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIPK1
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Research Area——
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Indication——
Chemical Information
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CAS Number375835-43-1
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Formula Weight384.5
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Molecular FormulaC18H16N4O2S2
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (325.11 mM; Need ultrasonic)
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SMILESO=C(NC1=NC=CS1)CSC2=C(C#N)C(C3=CC=C(C)C=C3)CC(N2)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Huyan Meng, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 2021 Jun 1;7(1):41.
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